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α-galactosidase A

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (1) Endogenous Metabolite (2) Fluorescent Dye (1)
By Research Areas:	Metabolic Disease (2)

8

Inhibitors & Agonists

2

Biochemical Assay Reagents

1

Natural
Products

2

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Migalastat hydrochloride GR181413A	Others	Others
Migalastat hydrochloride (GR181413A) is a potent and competitive inhibitor of α-galactosidase A (α-Gal A) with an IC₅₀ of 0.04 μM for human α-Gal A.

4-Methylumbelliferyl-α-D-galactopyranoside 4MU-α-Gal	Fluorescent Dye	Others
4-Methylumbelliferyl-α-D-galactopyranoside (4MU-α-Gal), a substrate for α-galactosidase A (GLA), is a blue pro-fluorogenic substrate. 4-Methylumbelliferyl-α-D-galactopyranoside forms two products, galactose and fluorescent 4MU, upon cleavage by GLA .

α-Galactosidase, Aspergillus niger EC 3.2.1.22	Endogenous Metabolite	Others
α-Galactosidase, Aspergillus niger (EC 3.2.1.22), that is, α-galactosidase, is a glycoside hydrolase that widely exists in animals, plants and microorganisms, and is often used in biochemical research. α-Galactosidase catalyzes the hydrolysis of α-1,6-linked terminal galactose residues, including galactooligosaccharides, galactomannans, and galactolipids. Catalyzes many catabolic processes including cleavage of glycoproteins, glycolipids and polysaccharides .

Agalsidase alfa	Others	Metabolic Disease
Agalsidase alfa has an amino acid sequence identical to that of native α-galactosidase A. Agalsidase alfa can be used for Fabry disease research .

Migalastat GR181413A free base	Others	Others
Migalastat (GR181413A free base) is an orally active and competitive inhibitor of α-galactosidase A (α-Gal A) with an IC₅₀ of 0.04 μM for human α-Gal A .

Raffinose 1 Publications Verification Melitose	Endogenous Metabolite	Metabolic Disease
Raffinose (Melitose), a non-digestible short-chain oligosaccharide, is a trisaccharide composed of galactose, glucose, and fructose and can be found in many plants. Raffinose (Melitose) can be hydrolyzed to D-galactose and sucrose by the enzyme α-galactosidase (α-GAL) .

4-Nitrophenyl α-D-galactopyranoside PNP-alpha-D-Gal; PNP-α-D-Gal	Biochemical Assay Reagents	Others
4-Nitrophenyl α-D-galactopyranoside (PNP-alpha-D-Gal) is an artificial substrate of 4-nitrophenyl (pNP) glycopyranoside for detecting α-galactosidase activity. The amount of released pNP is significantly increased when 4-Nitrophenyl α-D-galactopyranoside is used as substrates .

Methyl α-D-galactopyranoside monohydrate	Others	Others
Methyl α-D-galactopyranoside monohydrate is an alpha-D-galactoside having a methyl substituent at the anomeric position. Methyl α-D-galactopyranoside inhibits debaryomyces hansenii UFV-1 extracellular and intracellular *α-galactosidases* with K_i values of 0.82 and 1.12 mM, respectively .

Cat. No.	Product Name	Type

4-Nitrophenyl α-D-galactopyranoside PNP-alpha-D-Gal; PNP-α-D-Gal	Enzyme Substrates
4-Nitrophenyl α-D-galactopyranoside (PNP-alpha-D-Gal) is an artificial substrate of 4-nitrophenyl (pNP) glycopyranoside for detecting α-galactosidase activity. The amount of released pNP is significantly increased when 4-Nitrophenyl α-D-galactopyranoside is used as substrates .

HY-E70180

α-Galactosidase A

EC:3.2.1.22; GLA
Enzyme Substrates

alpha-Galactosidase A is a lysosomal exoglycosidase and hydrolyses the terminal α-galactosyl moieties of glycoconjugates .

Species:	Human (1) Mouse (1)
Tag:	His (2)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

	*GLA/alpha-Galactosidase* A Protein, Mouse (HEK293, His)** Alpha-galactosidase A; GALA; GLA; Melibiase	Mouse	HEK293
	GLA/alpha-Galactosidase A Protein is responsible for the breakdown of alpha-galactoside in the lysosome. GLA/alpha-Galactosidase A Protein participates in the negative regulation of nitric oxide biosynthesis and nitric oxide synthase activity. A deficiency of GLA/alpha-Galactosidase A Protein causes Fabry disease. GLA/alpha-Galactosidase A Protein, Mouse (HEK293, His) is the recombinant mouse-derived GLA/alpha-Galactosidase A protein, expressed by HEK293, with C-His labeled tag. The total length of GLA/alpha-Galactosidase A Protein, Mouse (HEK293, His) is 388 a.a., with molecular weight of 46-52 kDa.

	Alpha-Galactosidase A Protein, Human (HEK293, His) rHualpha-galactosidase A, His; GLA; alpha-galactosidase A	Human	HEK293
	Alpha-Galactosidase A Protein, Human (HEK293, His), a recombinant human alpha-Galactosidase A produced in HEK293 cells, has a His tag at the C-terminus. Alpha-Galactosidase A Protein, Human (HEK293, His) is the lysosomal exoglycosidase responsible for the hydrolysis of terminal α-galactosyl residues from glycoconjugates and is the defective enzyme causing Fabry disease.

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